Right ventricular longitudinal strain for risk stratification in low-flow, low-gradient aortic stenosis with low ejection fraction
Identifieur interne : 000B29 ( Main/Exploration ); précédent : 000B28; suivant : 000B30Right ventricular longitudinal strain for risk stratification in low-flow, low-gradient aortic stenosis with low ejection fraction
Auteurs : Abdellaziz Dahou [Canada] ; Marie-Annick Clavel [Canada] ; Romain Capoulade [Canada] ; Philipp Emanuel Bartko [Autriche] ; Julien Magne [France] ; Gerald Mundigler [Autriche] ; Jutta Bergler-Klein [Autriche] ; Ian Burwash [Canada] ; Julia Mascherbauer [Autriche] ; Henrique Ribeiro [Canada] ; Kim O'Connor [Canada] ; Helmut Baumgartner [Allemagne] ; Mario Sénéchal [Canada] ; Jean Dumesnil [Canada] ; Raphael Rosenhek [Autriche] ; Patrick Mathieu [Canada] ; Eric Larose [Canada] ; Josep Rodes-Cabau ; Philippe Pibarot [Canada]Source :
- Heart [ 1355-6037 ] ; 2016-03-11.
Abstract
BACKGROUND:Left ventricular global longitudinal strain (LVLS) is a powerful predictor of outcome in patients with low-flow, low-gradient aortic stenosis (LF-LG AS) and low LV ejection fraction (LVEF). However, the impact of right ventricular (RV) function on the outcome of these patients remains unknown.OBJECTIVES:The aim of this study was to examine the impact of RV function as evaluated by RV free wall longitudinal strain (RVLS) on mortality in patients with LF-LG AS and low LVEF.METHODS:211 patients with LF-LG AS (mean gradient < 40 mm Hg and indexed aortic valve area (AVA) ≤ 0.6 cm²/m²) and low LVEF (≤ 40%)) were prospectively recruited in the True or Pseudo-severe Aortic Stenosis study. AS severity was assessed using the projected AVA (AVAproj) at normal flow rate. Among the 211 patients, 128 had RVLS measurement available at rest and were included in this analysis. RVLS measurement at dobutamine stress echocardiography (DSE) was available in 58 of the 128 patients.RESULTS:Two-year survival was lower in patients with RVLS < |13|% (53% ± 9%) compared with those with RVLS > |13|% (69% ± 5%) (p = 0.04). In multivariable Cox analysis stratified for the type of treatment (aortic valve replacement vs conservative) and adjusted for age, AS severity, previous myocardial infarction and LVLS, rest RVLS < |13|% (HR = 2.70; 95% CI 1.19 to 6.11; p = 0.018) was independently associated with all-cause mortality. RVLS had incremental prognostic value over baseline risk factors and LVLS (χ² = 20.13 vs 13.56; p = 0.01). Reduced stress RVLS was also associated with increased risk of mortality (stress RVLS <| 14|%: HR = 2.98; 95% CI 1.30 to 6.52; p = 0.01). In multivariable Cox analysis, stress RVLS < |14|% remained independently associated with mortality (HR = 2.94; 95% CI 1.23 to 7.02; p = 0.015). After further adjustment for rest RVLS, stress RVLS < |14|% remained independently associated with mortality (HR = 3.29; 95% CI 1.17 to 9.25; p = 0.024), whereas rest RVLS was not (p > 0.05).CONCLUSIONS:In this series of patients with LF-LG AS and low LVEF, reduced RVLS was independently associated with increased risk of mortality. Furthermore, stress RVLS provided incremental prognostic value beyond that obtained from rest RVLS. Thus, RVLS measurement at rest and at DSE may be helpful to enhance risk stratification in this high-risk population.
Url:
DOI: 10.1136/heartjnl-2015-308309
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Hal, to step Corpus: 000133
- to stream Hal, to step Curation: 000133
- to stream Hal, to step Checkpoint: 000081
- to stream Main, to step Merge: 000B30
- to stream Main, to step Curation: 000B29
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Right ventricular longitudinal strain for risk stratification in low-flow, low-gradient aortic stenosis with low ejection fraction</title><author><name sortKey="Dahou, Abdellaziz" sort="Dahou, Abdellaziz" uniqKey="Dahou A" first="Abdellaziz" last="Dahou">Abdellaziz Dahou</name><affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-565657" status="INCOMING"> <orgName>Centre de Recherche de l’Institut Universitaire de Cardiologie et de Pneumologie de Québec, Laval University, Montréal, QC G1V 4G5, Canada</orgName> <desc> <address> <addrLine>, Laval University, Montréal, QC G1V 4G5, Canada</addrLine> <country key="CA"></country> </address> </desc> </hal:affiliation><country>Canada</country></affiliation></author><author><name sortKey="Clavel, Marie Annick" sort="Clavel, Marie Annick" uniqKey="Clavel M" first="Marie-Annick" last="Clavel">Marie-Annick Clavel</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-539572" status="VALID"> <orgName>Quebec Heart and Lung Institute</orgName> <desc> <address> <addrLine>-</addrLine> <country key="CA"></country> </address> <ref type="url">http://iucpq.qc.ca/en</ref> </desc> <listRelation> <relation active="#struct-466815" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-466815" type="direct"><org type="institution" xml:id="struct-466815" status="VALID"> <orgName>Laval University [Québec]</orgName> <date type="start">2016-09-27</date> <desc> <address> <addrLine>2325, rue de l'UniversitéQuébec (Québec) G1V 0A6 </addrLine> <country key="CA"></country> </address> <ref type="url">http://www2.ulaval.ca/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>Canada</country></affiliation></author><author><name sortKey="Capoulade, Romain" sort="Capoulade, Romain" uniqKey="Capoulade R" first="Romain" last="Capoulade">Romain Capoulade</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-511467" status="INCOMING"> <orgName>Département de Psychiatrie et de Neurosciences - Centre de recherche de l’Institut universitaire de cardiologie et de pneumologie de Québe</orgName> <desc> <address> <country key="CA"></country> </address> </desc> <listRelation> <relation active="#struct-93488" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-93488" type="direct"><org type="institution" xml:id="struct-93488" status="VALID"> <orgName>Université Laval</orgName> <desc> <address> <addrLine>2325, rue de l'Université Québec G1V 0A6</addrLine> <country key="CA"></country> </address> <ref type="url">http://www2.ulaval.ca/accueil.html</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>Canada</country></affiliation></author><author><name sortKey="Bartko, Philipp Emanuel" sort="Bartko, Philipp Emanuel" uniqKey="Bartko P" first="Philipp Emanuel" last="Bartko">Philipp Emanuel Bartko</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-447256" status="INCOMING"> <orgName>Department of Cardiology [Vienna]</orgName> <desc> <address> <addrLine>Währinger Gürtel 18–20, A-1090 Vienna, Austria</addrLine> <country key="AT"></country> </address> </desc> <listRelation> <relation active="#struct-93275" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-93275" type="direct"><org type="institution" xml:id="struct-93275" status="VALID"> <orgName>Medizinische Universität Wien = Medical University of Vienna</orgName> <desc> <address> <addrLine>Spitalgasse 23, A-1090 Vienna</addrLine> <country key="AT"></country> </address> <ref type="url">http://www.meduniwien.ac.at/homepage/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>Autriche</country></affiliation></author><author><name sortKey="Magne, Julien" sort="Magne, Julien" uniqKey="Magne J" first="Julien" last="Magne">Julien Magne</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-185397" status="VALID"> <idno type="IdRef">185648967</idno> <idno type="RNSR">201220173E</idno> <orgName>Neuroépidémiologie Tropicale</orgName> <orgName type="acronym">NET</orgName> <date type="start">2012-01-01</date> <desc> <address> <addrLine>Université de Limoges - Faculté de Médecine - 2 rue du Dr Marcland 87025 Limoges</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.unilim.fr/ient/</ref> </desc> <listRelation> <relation active="#struct-526218" type="direct"></relation> <relation active="#struct-5928" type="indirect"></relation> <relation active="#struct-300906" type="direct"></relation> <relation active="#struct-301268" type="direct"></relation> <relation name="U1094" active="#struct-303623" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-526218" type="direct"><org type="regrouplaboratory" xml:id="struct-526218" status="VALID"> <idno type="IdRef">224565699</idno> <orgName>Institut Génomique, Environnement, Immunité, Santé, Thérapeutique </orgName> <orgName type="acronym">GEIST</orgName> <date type="start">2018-01-01</date> <desc> <address> <addrLine>Université de Limoges - Faculté de Médecine - 2 rue du Dr Marcland 87025 Limoges cedex </addrLine> <country key="FR"></country> </address> <ref type="url">https://www.unilim.fr/recherche/laboratoires/geist/</ref> </desc> <listRelation> <relation active="#struct-5928" type="direct"></relation> </listRelation> </org></tutelle><tutelle active="#struct-5928" type="indirect"><org type="institution" xml:id="struct-5928" status="VALID"> <idno type="IdRef">026403315</idno> <idno type="ISNI">0000000121654861</idno> <orgName>Université de Limoges</orgName> <orgName type="acronym">UNILIM</orgName> <date type="start">1968-10-01</date> <desc> <address> <addrLine>33 rue François Mitterrand BP23204 87032 Limoges</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.unilim.fr</ref> </desc> </org></tutelle><tutelle active="#struct-300906" type="direct"><org type="institution" xml:id="struct-300906" status="VALID"> <orgName>CHU Limoges</orgName> <desc> <address> <addrLine>Centre Hospitalier Universitaire Dupuytren - 2 avenue Martin Luther King 87042 LIMOGES </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.chu-limoges.fr/</ref> </desc> </org></tutelle><tutelle active="#struct-301268" type="direct"><org type="institution" xml:id="struct-301268" status="VALID"> <orgName>Institut d'Epidémiologie Neurologique et de Neurologie Tropicale</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle name="U1094" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno> <orgName>Institut National de la Santé et de la Recherche Médicale</orgName> <orgName type="acronym">INSERM</orgName> <desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.inserm.fr</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country><placeName><settlement type="city">Limoges</settlement><region type="region" nuts="2">Limousin</region></placeName><orgName type="university">Université de Limoges</orgName></affiliation></author><author><name sortKey="Mundigler, Gerald" sort="Mundigler, Gerald" uniqKey="Mundigler G" first="Gerald" last="Mundigler">Gerald Mundigler</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-447256" status="INCOMING"> <orgName>Department of Cardiology [Vienna]</orgName> <desc> <address> <addrLine>Währinger Gürtel 18–20, A-1090 Vienna, Austria</addrLine> <country key="AT"></country> </address> </desc> <listRelation> <relation active="#struct-93275" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-93275" type="direct"><org type="institution" xml:id="struct-93275" status="VALID"> <orgName>Medizinische Universität Wien = Medical University of Vienna</orgName> <desc> <address> <addrLine>Spitalgasse 23, A-1090 Vienna</addrLine> <country key="AT"></country> </address> <ref type="url">http://www.meduniwien.ac.at/homepage/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>Autriche</country></affiliation></author><author><name sortKey="Bergler Klein, Jutta" sort="Bergler Klein, Jutta" uniqKey="Bergler Klein J" first="Jutta" last="Bergler-Klein">Jutta Bergler-Klein</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-447256" status="INCOMING"> <orgName>Department of Cardiology [Vienna]</orgName> <desc> <address> <addrLine>Währinger Gürtel 18–20, A-1090 Vienna, Austria</addrLine> <country key="AT"></country> </address> </desc> <listRelation> <relation active="#struct-93275" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-93275" type="direct"><org type="institution" xml:id="struct-93275" status="VALID"> <orgName>Medizinische Universität Wien = Medical University of Vienna</orgName> <desc> <address> <addrLine>Spitalgasse 23, A-1090 Vienna</addrLine> <country key="AT"></country> </address> <ref type="url">http://www.meduniwien.ac.at/homepage/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>Autriche</country></affiliation></author><author><name sortKey="Burwash, Ian" sort="Burwash, Ian" uniqKey="Burwash I" first="Ian" last="Burwash">Ian Burwash</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-411579" status="INCOMING"> <orgName>University of Ottawa Heart Institute</orgName> <desc> <address> <addrLine>40 Ruskin Street, Ottawa, K1Y 4W7, Canada</addrLine> <country key="CA"></country> </address> </desc> <listRelation> <relation active="#struct-237693" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-237693" type="direct"><org type="institution" xml:id="struct-237693" status="VALID"> <orgName>University of Ottawa [Ottawa]</orgName> <orgName type="acronym">uOttawa</orgName> <desc> <address> <addrLine>75 Laurier Avenue East, Ottawa, ON K1N 6N5</addrLine> <country key="CA"></country> </address> <ref type="url">http://www.uottawa.ca</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>Canada</country></affiliation></author><author><name sortKey="Mascherbauer, Julia" sort="Mascherbauer, Julia" uniqKey="Mascherbauer J" first="Julia" last="Mascherbauer">Julia Mascherbauer</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-447256" status="INCOMING"> <orgName>Department of Cardiology [Vienna]</orgName> <desc> <address> <addrLine>Währinger Gürtel 18–20, A-1090 Vienna, Austria</addrLine> <country key="AT"></country> </address> </desc> <listRelation> <relation active="#struct-93275" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-93275" type="direct"><org type="institution" xml:id="struct-93275" status="VALID"> <orgName>Medizinische Universität Wien = Medical University of Vienna</orgName> <desc> <address> <addrLine>Spitalgasse 23, A-1090 Vienna</addrLine> <country key="AT"></country> </address> <ref type="url">http://www.meduniwien.ac.at/homepage/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>Autriche</country></affiliation></author><author><name sortKey="Ribeiro, Henrique" sort="Ribeiro, Henrique" uniqKey="Ribeiro H" first="Henrique" last="Ribeiro">Henrique Ribeiro</name><affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-565657" status="INCOMING"> <orgName>Centre de Recherche de l’Institut Universitaire de Cardiologie et de Pneumologie de Québec, Laval University, Montréal, QC G1V 4G5, Canada</orgName> <desc> <address> <addrLine>, Laval University, Montréal, QC G1V 4G5, Canada</addrLine> <country key="CA"></country> </address> </desc> </hal:affiliation><country>Canada</country></affiliation></author><author><name sortKey="O Connor, Kim" sort="O Connor, Kim" uniqKey="O Connor K" first="Kim" last="O'Connor">Kim O'Connor</name><affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-565657" status="INCOMING"> <orgName>Centre de Recherche de l’Institut Universitaire de Cardiologie et de Pneumologie de Québec, Laval University, Montréal, QC G1V 4G5, Canada</orgName> <desc> <address> <addrLine>, Laval University, Montréal, QC G1V 4G5, Canada</addrLine> <country key="CA"></country> </address> </desc> </hal:affiliation><country>Canada</country></affiliation></author><author><name sortKey="Baumgartner, Helmut" sort="Baumgartner, Helmut" uniqKey="Baumgartner H" first="Helmut" last="Baumgartner">Helmut Baumgartner</name><affiliation wicri:level="1"><hal:affiliation type="regrouplaboratory" xml:id="struct-562589" status="INCOMING"> <orgName>Molecular and Translational Cardiology [Münster, Germany]</orgName> <orgName type="acronym">Department of Cardiovascular Medicine</orgName> <desc> <address> <country key="DE"></country> </address> </desc> <listRelation> <relation active="#struct-329896" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-329896" type="direct"><org type="institution" xml:id="struct-329896" status="INCOMING"> <orgName>University Hospital of Münster</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>Allemagne</country></affiliation></author><author><name sortKey="Senechal, Mario" sort="Senechal, Mario" uniqKey="Senechal M" first="Mario" last="Sénéchal">Mario Sénéchal</name><affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-565657" status="INCOMING"> <orgName>Centre de Recherche de l’Institut Universitaire de Cardiologie et de Pneumologie de Québec, Laval University, Montréal, QC G1V 4G5, Canada</orgName> <desc> <address> <addrLine>, Laval University, Montréal, QC G1V 4G5, Canada</addrLine> <country key="CA"></country> </address> </desc> </hal:affiliation><country>Canada</country></affiliation></author><author><name sortKey="Dumesnil, Jean" sort="Dumesnil, Jean" uniqKey="Dumesnil J" first="Jean" last="Dumesnil">Jean Dumesnil</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-10196" status="INCOMING"> <orgName>Quebec Heart Institute/Laval Hospital</orgName> <desc> <address> <addrLine>Sainte-Foy, Quebec</addrLine> <country key="CA"></country> </address> </desc> <listRelation> <relation active="#struct-306811" type="direct"></relation> <relation active="#struct-466815" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-306811" type="direct"><org type="institution" xml:id="struct-306811" status="INCOMING"> <orgName>Quebec Heart Institute</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-466815" type="direct"><org type="institution" xml:id="struct-466815" status="VALID"> <orgName>Laval University [Québec]</orgName> <date type="start">2016-09-27</date> <desc> <address> <addrLine>2325, rue de l'UniversitéQuébec (Québec) G1V 0A6 </addrLine> <country key="CA"></country> </address> <ref type="url">http://www2.ulaval.ca/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>Canada</country></affiliation></author><author><name sortKey="Rosenhek, Raphael" sort="Rosenhek, Raphael" uniqKey="Rosenhek R" first="Raphael" last="Rosenhek">Raphael Rosenhek</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-447256" status="INCOMING"> <orgName>Department of Cardiology [Vienna]</orgName> <desc> <address> <addrLine>Währinger Gürtel 18–20, A-1090 Vienna, Austria</addrLine> <country key="AT"></country> </address> </desc> <listRelation> <relation active="#struct-93275" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-93275" type="direct"><org type="institution" xml:id="struct-93275" status="VALID"> <orgName>Medizinische Universität Wien = Medical University of Vienna</orgName> <desc> <address> <addrLine>Spitalgasse 23, A-1090 Vienna</addrLine> <country key="AT"></country> </address> <ref type="url">http://www.meduniwien.ac.at/homepage/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>Autriche</country></affiliation></author><author><name sortKey="Mathieu, Patrick" sort="Mathieu, Patrick" uniqKey="Mathieu P" first="Patrick" last="Mathieu">Patrick Mathieu</name><affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-565657" status="INCOMING"> <orgName>Centre de Recherche de l’Institut Universitaire de Cardiologie et de Pneumologie de Québec, Laval University, Montréal, QC G1V 4G5, Canada</orgName> <desc> <address> <addrLine>, Laval University, Montréal, QC G1V 4G5, Canada</addrLine> <country key="CA"></country> </address> </desc> </hal:affiliation><country>Canada</country></affiliation></author><author><name sortKey="Larose, Eric" sort="Larose, Eric" uniqKey="Larose E" first="Eric" last="Larose">Eric Larose</name><affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-565657" status="INCOMING"> <orgName>Centre de Recherche de l’Institut Universitaire de Cardiologie et de Pneumologie de Québec, Laval University, Montréal, QC G1V 4G5, Canada</orgName> <desc> <address> <addrLine>, Laval University, Montréal, QC G1V 4G5, Canada</addrLine> <country key="CA"></country> </address> </desc> </hal:affiliation><country>Canada</country></affiliation></author><author><name sortKey="Rodes Cabau, Josep" sort="Rodes Cabau, Josep" uniqKey="Rodes Cabau J" first="Josep" last="Rodes-Cabau">Josep Rodes-Cabau</name><affiliation><hal:affiliation type="regrouplaboratory" xml:id="struct-541012" status="VALID"> <orgName>Institut Universitaire de Cardiologie et de Pneumologie de Québec</orgName> <orgName type="acronym">IUCPQ</orgName> <date type="start">2008</date> <desc> <address> <addrLine>2725, chemin Sainte-FoyQuébec (Québec) CanadaG1V 4G5</addrLine> </address> </desc> <listRelation> <relation active="#struct-93488" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-93488" type="direct"><org type="institution" xml:id="struct-93488" status="VALID"> <orgName>Université Laval</orgName> <desc> <address> <addrLine>2325, rue de l'Université Québec G1V 0A6</addrLine> <country key="CA"></country> </address> <ref type="url">http://www2.ulaval.ca/accueil.html</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Pibarot, Philippe" sort="Pibarot, Philippe" uniqKey="Pibarot P" first="Philippe" last="Pibarot">Philippe Pibarot</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-10196" status="INCOMING"> <orgName>Quebec Heart Institute/Laval Hospital</orgName> <desc> <address> <addrLine>Sainte-Foy, Quebec</addrLine> <country key="CA"></country> </address> </desc> <listRelation> <relation active="#struct-306811" type="direct"></relation> <relation active="#struct-466815" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-306811" type="direct"><org type="institution" xml:id="struct-306811" status="INCOMING"> <orgName>Quebec Heart Institute</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-466815" type="direct"><org type="institution" xml:id="struct-466815" status="VALID"> <orgName>Laval University [Québec]</orgName> <date type="start">2016-09-27</date> <desc> <address> <addrLine>2325, rue de l'UniversitéQuébec (Québec) G1V 0A6 </addrLine> <country key="CA"></country> </address> <ref type="url">http://www2.ulaval.ca/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>Canada</country></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">HAL</idno><idno type="RBID">Hal:hal-02318505</idno><idno type="halId">hal-02318505</idno><idno type="halUri">https://hal-unilim.archives-ouvertes.fr/hal-02318505</idno><idno type="url">https://hal-unilim.archives-ouvertes.fr/hal-02318505</idno><idno type="doi">10.1136/heartjnl-2015-308309</idno><date when="2016-03-11">2016-03-11</date><idno type="wicri:Area/Hal/Corpus">000133</idno><idno type="wicri:Area/Hal/Curation">000133</idno><idno type="wicri:Area/Hal/Checkpoint">000081</idno><idno type="wicri:explorRef" wicri:stream="Hal" wicri:step="Checkpoint">000081</idno><idno type="wicri:doubleKey">1355-6037:2016:Dahou A:right:ventricular:longitudinal</idno><idno type="wicri:Area/Main/Merge">000B30</idno><idno type="wicri:Area/Main/Curation">000B29</idno><idno type="wicri:Area/Main/Exploration">000B29</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Right ventricular longitudinal strain for risk stratification in low-flow, low-gradient aortic stenosis with low ejection fraction</title><author><name sortKey="Dahou, Abdellaziz" sort="Dahou, Abdellaziz" uniqKey="Dahou A" first="Abdellaziz" last="Dahou">Abdellaziz Dahou</name><affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-565657" status="INCOMING"> <orgName>Centre de Recherche de l’Institut Universitaire de Cardiologie et de Pneumologie de Québec, Laval University, Montréal, QC G1V 4G5, Canada</orgName> <desc> <address> <addrLine>, Laval University, Montréal, QC G1V 4G5, Canada</addrLine> <country key="CA"></country> </address> </desc> </hal:affiliation><country>Canada</country></affiliation></author><author><name sortKey="Clavel, Marie Annick" sort="Clavel, Marie Annick" uniqKey="Clavel M" first="Marie-Annick" last="Clavel">Marie-Annick Clavel</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-539572" status="VALID"> <orgName>Quebec Heart and Lung Institute</orgName> <desc> <address> <addrLine>-</addrLine> <country key="CA"></country> </address> <ref type="url">http://iucpq.qc.ca/en</ref> </desc> <listRelation> <relation active="#struct-466815" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-466815" type="direct"><org type="institution" xml:id="struct-466815" status="VALID"> <orgName>Laval University [Québec]</orgName> <date type="start">2016-09-27</date> <desc> <address> <addrLine>2325, rue de l'UniversitéQuébec (Québec) G1V 0A6 </addrLine> <country key="CA"></country> </address> <ref type="url">http://www2.ulaval.ca/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>Canada</country></affiliation></author><author><name sortKey="Capoulade, Romain" sort="Capoulade, Romain" uniqKey="Capoulade R" first="Romain" last="Capoulade">Romain Capoulade</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-511467" status="INCOMING"> <orgName>Département de Psychiatrie et de Neurosciences - Centre de recherche de l’Institut universitaire de cardiologie et de pneumologie de Québe</orgName> <desc> <address> <country key="CA"></country> </address> </desc> <listRelation> <relation active="#struct-93488" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-93488" type="direct"><org type="institution" xml:id="struct-93488" status="VALID"> <orgName>Université Laval</orgName> <desc> <address> <addrLine>2325, rue de l'Université Québec G1V 0A6</addrLine> <country key="CA"></country> </address> <ref type="url">http://www2.ulaval.ca/accueil.html</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>Canada</country></affiliation></author><author><name sortKey="Bartko, Philipp Emanuel" sort="Bartko, Philipp Emanuel" uniqKey="Bartko P" first="Philipp Emanuel" last="Bartko">Philipp Emanuel Bartko</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-447256" status="INCOMING"> <orgName>Department of Cardiology [Vienna]</orgName> <desc> <address> <addrLine>Währinger Gürtel 18–20, A-1090 Vienna, Austria</addrLine> <country key="AT"></country> </address> </desc> <listRelation> <relation active="#struct-93275" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-93275" type="direct"><org type="institution" xml:id="struct-93275" status="VALID"> <orgName>Medizinische Universität Wien = Medical University of Vienna</orgName> <desc> <address> <addrLine>Spitalgasse 23, A-1090 Vienna</addrLine> <country key="AT"></country> </address> <ref type="url">http://www.meduniwien.ac.at/homepage/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>Autriche</country></affiliation></author><author><name sortKey="Magne, Julien" sort="Magne, Julien" uniqKey="Magne J" first="Julien" last="Magne">Julien Magne</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-185397" status="VALID"> <idno type="IdRef">185648967</idno> <idno type="RNSR">201220173E</idno> <orgName>Neuroépidémiologie Tropicale</orgName> <orgName type="acronym">NET</orgName> <date type="start">2012-01-01</date> <desc> <address> <addrLine>Université de Limoges - Faculté de Médecine - 2 rue du Dr Marcland 87025 Limoges</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.unilim.fr/ient/</ref> </desc> <listRelation> <relation active="#struct-526218" type="direct"></relation> <relation active="#struct-5928" type="indirect"></relation> <relation active="#struct-300906" type="direct"></relation> <relation active="#struct-301268" type="direct"></relation> <relation name="U1094" active="#struct-303623" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-526218" type="direct"><org type="regrouplaboratory" xml:id="struct-526218" status="VALID"> <idno type="IdRef">224565699</idno> <orgName>Institut Génomique, Environnement, Immunité, Santé, Thérapeutique </orgName> <orgName type="acronym">GEIST</orgName> <date type="start">2018-01-01</date> <desc> <address> <addrLine>Université de Limoges - Faculté de Médecine - 2 rue du Dr Marcland 87025 Limoges cedex </addrLine> <country key="FR"></country> </address> <ref type="url">https://www.unilim.fr/recherche/laboratoires/geist/</ref> </desc> <listRelation> <relation active="#struct-5928" type="direct"></relation> </listRelation> </org></tutelle><tutelle active="#struct-5928" type="indirect"><org type="institution" xml:id="struct-5928" status="VALID"> <idno type="IdRef">026403315</idno> <idno type="ISNI">0000000121654861</idno> <orgName>Université de Limoges</orgName> <orgName type="acronym">UNILIM</orgName> <date type="start">1968-10-01</date> <desc> <address> <addrLine>33 rue François Mitterrand BP23204 87032 Limoges</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.unilim.fr</ref> </desc> </org></tutelle><tutelle active="#struct-300906" type="direct"><org type="institution" xml:id="struct-300906" status="VALID"> <orgName>CHU Limoges</orgName> <desc> <address> <addrLine>Centre Hospitalier Universitaire Dupuytren - 2 avenue Martin Luther King 87042 LIMOGES </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.chu-limoges.fr/</ref> </desc> </org></tutelle><tutelle active="#struct-301268" type="direct"><org type="institution" xml:id="struct-301268" status="VALID"> <orgName>Institut d'Epidémiologie Neurologique et de Neurologie Tropicale</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle name="U1094" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno> <orgName>Institut National de la Santé et de la Recherche Médicale</orgName> <orgName type="acronym">INSERM</orgName> <desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.inserm.fr</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country><placeName><settlement type="city">Limoges</settlement><region type="region" nuts="2">Limousin</region></placeName><orgName type="university">Université de Limoges</orgName></affiliation></author><author><name sortKey="Mundigler, Gerald" sort="Mundigler, Gerald" uniqKey="Mundigler G" first="Gerald" last="Mundigler">Gerald Mundigler</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-447256" status="INCOMING"> <orgName>Department of Cardiology [Vienna]</orgName> <desc> <address> <addrLine>Währinger Gürtel 18–20, A-1090 Vienna, Austria</addrLine> <country key="AT"></country> </address> </desc> <listRelation> <relation active="#struct-93275" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-93275" type="direct"><org type="institution" xml:id="struct-93275" status="VALID"> <orgName>Medizinische Universität Wien = Medical University of Vienna</orgName> <desc> <address> <addrLine>Spitalgasse 23, A-1090 Vienna</addrLine> <country key="AT"></country> </address> <ref type="url">http://www.meduniwien.ac.at/homepage/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>Autriche</country></affiliation></author><author><name sortKey="Bergler Klein, Jutta" sort="Bergler Klein, Jutta" uniqKey="Bergler Klein J" first="Jutta" last="Bergler-Klein">Jutta Bergler-Klein</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-447256" status="INCOMING"> <orgName>Department of Cardiology [Vienna]</orgName> <desc> <address> <addrLine>Währinger Gürtel 18–20, A-1090 Vienna, Austria</addrLine> <country key="AT"></country> </address> </desc> <listRelation> <relation active="#struct-93275" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-93275" type="direct"><org type="institution" xml:id="struct-93275" status="VALID"> <orgName>Medizinische Universität Wien = Medical University of Vienna</orgName> <desc> <address> <addrLine>Spitalgasse 23, A-1090 Vienna</addrLine> <country key="AT"></country> </address> <ref type="url">http://www.meduniwien.ac.at/homepage/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>Autriche</country></affiliation></author><author><name sortKey="Burwash, Ian" sort="Burwash, Ian" uniqKey="Burwash I" first="Ian" last="Burwash">Ian Burwash</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-411579" status="INCOMING"> <orgName>University of Ottawa Heart Institute</orgName> <desc> <address> <addrLine>40 Ruskin Street, Ottawa, K1Y 4W7, Canada</addrLine> <country key="CA"></country> </address> </desc> <listRelation> <relation active="#struct-237693" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-237693" type="direct"><org type="institution" xml:id="struct-237693" status="VALID"> <orgName>University of Ottawa [Ottawa]</orgName> <orgName type="acronym">uOttawa</orgName> <desc> <address> <addrLine>75 Laurier Avenue East, Ottawa, ON K1N 6N5</addrLine> <country key="CA"></country> </address> <ref type="url">http://www.uottawa.ca</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>Canada</country></affiliation></author><author><name sortKey="Mascherbauer, Julia" sort="Mascherbauer, Julia" uniqKey="Mascherbauer J" first="Julia" last="Mascherbauer">Julia Mascherbauer</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-447256" status="INCOMING"> <orgName>Department of Cardiology [Vienna]</orgName> <desc> <address> <addrLine>Währinger Gürtel 18–20, A-1090 Vienna, Austria</addrLine> <country key="AT"></country> </address> </desc> <listRelation> <relation active="#struct-93275" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-93275" type="direct"><org type="institution" xml:id="struct-93275" status="VALID"> <orgName>Medizinische Universität Wien = Medical University of Vienna</orgName> <desc> <address> <addrLine>Spitalgasse 23, A-1090 Vienna</addrLine> <country key="AT"></country> </address> <ref type="url">http://www.meduniwien.ac.at/homepage/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>Autriche</country></affiliation></author><author><name sortKey="Ribeiro, Henrique" sort="Ribeiro, Henrique" uniqKey="Ribeiro H" first="Henrique" last="Ribeiro">Henrique Ribeiro</name><affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-565657" status="INCOMING"> <orgName>Centre de Recherche de l’Institut Universitaire de Cardiologie et de Pneumologie de Québec, Laval University, Montréal, QC G1V 4G5, Canada</orgName> <desc> <address> <addrLine>, Laval University, Montréal, QC G1V 4G5, Canada</addrLine> <country key="CA"></country> </address> </desc> </hal:affiliation><country>Canada</country></affiliation></author><author><name sortKey="O Connor, Kim" sort="O Connor, Kim" uniqKey="O Connor K" first="Kim" last="O'Connor">Kim O'Connor</name><affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-565657" status="INCOMING"> <orgName>Centre de Recherche de l’Institut Universitaire de Cardiologie et de Pneumologie de Québec, Laval University, Montréal, QC G1V 4G5, Canada</orgName> <desc> <address> <addrLine>, Laval University, Montréal, QC G1V 4G5, Canada</addrLine> <country key="CA"></country> </address> </desc> </hal:affiliation><country>Canada</country></affiliation></author><author><name sortKey="Baumgartner, Helmut" sort="Baumgartner, Helmut" uniqKey="Baumgartner H" first="Helmut" last="Baumgartner">Helmut Baumgartner</name><affiliation wicri:level="1"><hal:affiliation type="regrouplaboratory" xml:id="struct-562589" status="INCOMING"> <orgName>Molecular and Translational Cardiology [Münster, Germany]</orgName> <orgName type="acronym">Department of Cardiovascular Medicine</orgName> <desc> <address> <country key="DE"></country> </address> </desc> <listRelation> <relation active="#struct-329896" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-329896" type="direct"><org type="institution" xml:id="struct-329896" status="INCOMING"> <orgName>University Hospital of Münster</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>Allemagne</country></affiliation></author><author><name sortKey="Senechal, Mario" sort="Senechal, Mario" uniqKey="Senechal M" first="Mario" last="Sénéchal">Mario Sénéchal</name><affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-565657" status="INCOMING"> <orgName>Centre de Recherche de l’Institut Universitaire de Cardiologie et de Pneumologie de Québec, Laval University, Montréal, QC G1V 4G5, Canada</orgName> <desc> <address> <addrLine>, Laval University, Montréal, QC G1V 4G5, Canada</addrLine> <country key="CA"></country> </address> </desc> </hal:affiliation><country>Canada</country></affiliation></author><author><name sortKey="Dumesnil, Jean" sort="Dumesnil, Jean" uniqKey="Dumesnil J" first="Jean" last="Dumesnil">Jean Dumesnil</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-10196" status="INCOMING"> <orgName>Quebec Heart Institute/Laval Hospital</orgName> <desc> <address> <addrLine>Sainte-Foy, Quebec</addrLine> <country key="CA"></country> </address> </desc> <listRelation> <relation active="#struct-306811" type="direct"></relation> <relation active="#struct-466815" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-306811" type="direct"><org type="institution" xml:id="struct-306811" status="INCOMING"> <orgName>Quebec Heart Institute</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-466815" type="direct"><org type="institution" xml:id="struct-466815" status="VALID"> <orgName>Laval University [Québec]</orgName> <date type="start">2016-09-27</date> <desc> <address> <addrLine>2325, rue de l'UniversitéQuébec (Québec) G1V 0A6 </addrLine> <country key="CA"></country> </address> <ref type="url">http://www2.ulaval.ca/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>Canada</country></affiliation></author><author><name sortKey="Rosenhek, Raphael" sort="Rosenhek, Raphael" uniqKey="Rosenhek R" first="Raphael" last="Rosenhek">Raphael Rosenhek</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-447256" status="INCOMING"> <orgName>Department of Cardiology [Vienna]</orgName> <desc> <address> <addrLine>Währinger Gürtel 18–20, A-1090 Vienna, Austria</addrLine> <country key="AT"></country> </address> </desc> <listRelation> <relation active="#struct-93275" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-93275" type="direct"><org type="institution" xml:id="struct-93275" status="VALID"> <orgName>Medizinische Universität Wien = Medical University of Vienna</orgName> <desc> <address> <addrLine>Spitalgasse 23, A-1090 Vienna</addrLine> <country key="AT"></country> </address> <ref type="url">http://www.meduniwien.ac.at/homepage/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>Autriche</country></affiliation></author><author><name sortKey="Mathieu, Patrick" sort="Mathieu, Patrick" uniqKey="Mathieu P" first="Patrick" last="Mathieu">Patrick Mathieu</name><affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-565657" status="INCOMING"> <orgName>Centre de Recherche de l’Institut Universitaire de Cardiologie et de Pneumologie de Québec, Laval University, Montréal, QC G1V 4G5, Canada</orgName> <desc> <address> <addrLine>, Laval University, Montréal, QC G1V 4G5, Canada</addrLine> <country key="CA"></country> </address> </desc> </hal:affiliation><country>Canada</country></affiliation></author><author><name sortKey="Larose, Eric" sort="Larose, Eric" uniqKey="Larose E" first="Eric" last="Larose">Eric Larose</name><affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-565657" status="INCOMING"> <orgName>Centre de Recherche de l’Institut Universitaire de Cardiologie et de Pneumologie de Québec, Laval University, Montréal, QC G1V 4G5, Canada</orgName> <desc> <address> <addrLine>, Laval University, Montréal, QC G1V 4G5, Canada</addrLine> <country key="CA"></country> </address> </desc> </hal:affiliation><country>Canada</country></affiliation></author><author><name sortKey="Rodes Cabau, Josep" sort="Rodes Cabau, Josep" uniqKey="Rodes Cabau J" first="Josep" last="Rodes-Cabau">Josep Rodes-Cabau</name><affiliation><hal:affiliation type="regrouplaboratory" xml:id="struct-541012" status="VALID"> <orgName>Institut Universitaire de Cardiologie et de Pneumologie de Québec</orgName> <orgName type="acronym">IUCPQ</orgName> <date type="start">2008</date> <desc> <address> <addrLine>2725, chemin Sainte-FoyQuébec (Québec) CanadaG1V 4G5</addrLine> </address> </desc> <listRelation> <relation active="#struct-93488" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-93488" type="direct"><org type="institution" xml:id="struct-93488" status="VALID"> <orgName>Université Laval</orgName> <desc> <address> <addrLine>2325, rue de l'Université Québec G1V 0A6</addrLine> <country key="CA"></country> </address> <ref type="url">http://www2.ulaval.ca/accueil.html</ref> </desc> </org></tutelle></tutelles></hal:affiliation></affiliation></author><author><name sortKey="Pibarot, Philippe" sort="Pibarot, Philippe" uniqKey="Pibarot P" first="Philippe" last="Pibarot">Philippe Pibarot</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-10196" status="INCOMING"> <orgName>Quebec Heart Institute/Laval Hospital</orgName> <desc> <address> <addrLine>Sainte-Foy, Quebec</addrLine> <country key="CA"></country> </address> </desc> <listRelation> <relation active="#struct-306811" type="direct"></relation> <relation active="#struct-466815" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-306811" type="direct"><org type="institution" xml:id="struct-306811" status="INCOMING"> <orgName>Quebec Heart Institute</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-466815" type="direct"><org type="institution" xml:id="struct-466815" status="VALID"> <orgName>Laval University [Québec]</orgName> <date type="start">2016-09-27</date> <desc> <address> <addrLine>2325, rue de l'UniversitéQuébec (Québec) G1V 0A6 </addrLine> <country key="CA"></country> </address> <ref type="url">http://www2.ulaval.ca/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>Canada</country></affiliation></author></analytic><idno type="DOI">10.1136/heartjnl-2015-308309</idno><series><title level="j">Heart</title><idno type="ISSN">1355-6037</idno><imprint><date type="datePub">2016-03-11</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"> <p>BACKGROUND:Left ventricular global longitudinal strain (LVLS) is a powerful predictor of outcome in patients with low-flow, low-gradient aortic stenosis (LF-LG AS) and low LV ejection fraction (LVEF). However, the impact of right ventricular (RV) function on the outcome of these patients remains unknown.OBJECTIVES:The aim of this study was to examine the impact of RV function as evaluated by RV free wall longitudinal strain (RVLS) on mortality in patients with LF-LG AS and low LVEF.METHODS:211 patients with LF-LG AS (mean gradient < 40 mm Hg and indexed aortic valve area (AVA) ≤ 0.6 cm²/m²) and low LVEF (≤ 40%)) were prospectively recruited in the True or Pseudo-severe Aortic Stenosis study. AS severity was assessed using the projected AVA (AVAproj) at normal flow rate. Among the 211 patients, 128 had RVLS measurement available at rest and were included in this analysis. RVLS measurement at dobutamine stress echocardiography (DSE) was available in 58 of the 128 patients.RESULTS:Two-year survival was lower in patients with RVLS < |13|% (53% ± 9%) compared with those with RVLS > |13|% (69% ± 5%) (p = 0.04). In multivariable Cox analysis stratified for the type of treatment (aortic valve replacement vs conservative) and adjusted for age, AS severity, previous myocardial infarction and LVLS, rest RVLS < |13|% (HR = 2.70; 95% CI 1.19 to 6.11; p = 0.018) was independently associated with all-cause mortality. RVLS had incremental prognostic value over baseline risk factors and LVLS (χ² = 20.13 vs 13.56; p = 0.01). Reduced stress RVLS was also associated with increased risk of mortality (stress RVLS <| 14|%: HR = 2.98; 95% CI 1.30 to 6.52; p = 0.01). In multivariable Cox analysis, stress RVLS < |14|% remained independently associated with mortality (HR = 2.94; 95% CI 1.23 to 7.02; p = 0.015). After further adjustment for rest RVLS, stress RVLS < |14|% remained independently associated with mortality (HR = 3.29; 95% CI 1.17 to 9.25; p = 0.024), whereas rest RVLS was not (p > 0.05).CONCLUSIONS:In this series of patients with LF-LG AS and low LVEF, reduced RVLS was independently associated with increased risk of mortality. Furthermore, stress RVLS provided incremental prognostic value beyond that obtained from rest RVLS. Thus, RVLS measurement at rest and at DSE may be helpful to enhance risk stratification in this high-risk population.</p> </div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Autriche</li><li>Canada</li><li>France</li></country><region><li>Limousin</li></region><settlement><li>Limoges</li></settlement><orgName><li>Université de Limoges</li></orgName></list><tree><noCountry><name sortKey="Rodes Cabau, Josep" sort="Rodes Cabau, Josep" uniqKey="Rodes Cabau J" first="Josep" last="Rodes-Cabau">Josep Rodes-Cabau</name></noCountry><country name="Canada"><noRegion><name sortKey="Dahou, Abdellaziz" sort="Dahou, Abdellaziz" uniqKey="Dahou A" first="Abdellaziz" last="Dahou">Abdellaziz Dahou</name></noRegion><name sortKey="Burwash, Ian" sort="Burwash, Ian" uniqKey="Burwash I" first="Ian" last="Burwash">Ian Burwash</name><name sortKey="Capoulade, Romain" sort="Capoulade, Romain" uniqKey="Capoulade R" first="Romain" last="Capoulade">Romain Capoulade</name><name sortKey="Clavel, Marie Annick" sort="Clavel, Marie Annick" uniqKey="Clavel M" first="Marie-Annick" last="Clavel">Marie-Annick Clavel</name><name sortKey="Dumesnil, Jean" sort="Dumesnil, Jean" uniqKey="Dumesnil J" first="Jean" last="Dumesnil">Jean Dumesnil</name><name sortKey="Larose, Eric" sort="Larose, Eric" uniqKey="Larose E" first="Eric" last="Larose">Eric Larose</name><name sortKey="Mathieu, Patrick" sort="Mathieu, Patrick" uniqKey="Mathieu P" first="Patrick" last="Mathieu">Patrick Mathieu</name><name sortKey="O Connor, Kim" sort="O Connor, Kim" uniqKey="O Connor K" first="Kim" last="O'Connor">Kim O'Connor</name><name sortKey="Pibarot, Philippe" sort="Pibarot, Philippe" uniqKey="Pibarot P" first="Philippe" last="Pibarot">Philippe Pibarot</name><name sortKey="Ribeiro, Henrique" sort="Ribeiro, Henrique" uniqKey="Ribeiro H" first="Henrique" last="Ribeiro">Henrique Ribeiro</name><name sortKey="Senechal, Mario" sort="Senechal, Mario" uniqKey="Senechal M" first="Mario" last="Sénéchal">Mario Sénéchal</name></country><country name="Autriche"><noRegion><name sortKey="Bartko, Philipp Emanuel" sort="Bartko, Philipp Emanuel" uniqKey="Bartko P" first="Philipp Emanuel" last="Bartko">Philipp Emanuel Bartko</name></noRegion><name sortKey="Bergler Klein, Jutta" sort="Bergler Klein, Jutta" uniqKey="Bergler Klein J" first="Jutta" last="Bergler-Klein">Jutta Bergler-Klein</name><name sortKey="Mascherbauer, Julia" sort="Mascherbauer, Julia" uniqKey="Mascherbauer J" first="Julia" last="Mascherbauer">Julia Mascherbauer</name><name sortKey="Mundigler, Gerald" sort="Mundigler, Gerald" uniqKey="Mundigler G" first="Gerald" last="Mundigler">Gerald Mundigler</name><name sortKey="Rosenhek, Raphael" sort="Rosenhek, Raphael" uniqKey="Rosenhek R" first="Raphael" last="Rosenhek">Raphael Rosenhek</name></country><country name="France"><region name="Limousin"><name sortKey="Magne, Julien" sort="Magne, Julien" uniqKey="Magne J" first="Julien" last="Magne">Julien Magne</name></region></country><country name="Allemagne"><noRegion><name sortKey="Baumgartner, Helmut" sort="Baumgartner, Helmut" uniqKey="Baumgartner H" first="Helmut" last="Baumgartner">Helmut Baumgartner</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/StressCovidV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000B29 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000B29 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= StressCovidV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= Hal:hal-02318505
|texte= Right ventricular longitudinal strain for risk stratification in low-flow, low-gradient aortic stenosis with low ejection fraction
}}
| This area was generated with Dilib version V0.6.33. |  |